打击
dǎjī
to strike; to hit; to deal a blow to; setback
verb/noun
Example
这次失败对他是很大的打击。
Zhè cì shībài duì tā shì hěn dà de dǎjī.
This failure was a huge blow to him.
Can be used both literally (to physically strike) and figuratively (emotional/psychological blow). Very common in describing setbacks or disappointments.